Back to Search Start Over

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Authors :
Timo Strohäker
Byung Chul Jung
Shu-Hao Liou
Claudio O. Fernandez
Dietmar Riedel
Stefan Becker
Glenda M. Halliday
Marina Bennati
Woojin S. Kim
Seung-Jae Lee
Markus Zweckstetter
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are characterized by the pathological accumulation of α-synuclein. Here the authors employ fluorescent probes, electron microscopy and NMR spectroscopy to study the properties of α-synuclein aggregates that were amplified from patient brain extracts and observe a greater structural diversity among PD patients compared to MSA patients.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.645030a3102e4d44bda780706743ff0d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13564-w