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The female protective effect against autism spectrum disorder
- Source :
- Cell Genomics, Vol 2, Iss 6, Pp 100134- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Summary: Autism spectrum disorder (ASD) is diagnosed three to four times more frequently in males than in females. Genetic studies of rare variants support a female protective effect (FPE) against ASD. However, sex differences in common inherited genetic risk for ASD are less studied, particularly within families. Leveraging the Danish iPSYCH resource, we found siblings of female ASD cases (n = 1,707) had higher rates of ASD than siblings of male ASD cases (n = 6,270; p
Details
- Language :
- English
- ISSN :
- 2666979X
- Volume :
- 2
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Cell Genomics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6453f898ded24923a75f37a8eadc8e6e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.xgen.2022.100134