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TET2 Expression in Bone Marrow Mononuclear Cells of Patients with Myelodysplastic Syndromes and Its Clinical Signifcances
- Source :
- Cancer Biology & Medicine, Vol 9, Iss 1, Pp 34-37 (2012)
- Publication Year :
- 2012
- Publisher :
- China Anti-Cancer Association, 2012.
-
Abstract
- Objective To investigate the expression of TET2 mRNA and protein in the bone marrow mononuclear cells (BMMNC) of patients with myelodysplastic syndrome (MDS) and its clinical significance.Methods The expression of TET2 mRNA and protein in bone marrow mononuclear cells (BMMNC) of 32 patients with MDS and 20 healthy donors was examined by qPCR and Western blot.Results The expression of TET2 mRNA in BMMNC was down-regulated in MDS patients compared with the donor group [(0.41±0.28)% vs. (1.07±0.56)%] (PPr=-0.398, Pr=-0.412, PConclusions The mRNA and protein expression of TET2 in BMMNC of MDS patients is decreased, which might be useful as an important parameter for the evaluation of MDS clone burden.
Details
- Language :
- English
- ISSN :
- 20953941
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Cancer Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.64552246643748cb976d84f9e5872635
- Document Type :
- article
- Full Text :
- https://doi.org/10.3969/j.issn.2095-3941.2012.01.006