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The genetics of interstitial lung diseases

Authors :
Raphael Borie
Pierre Le Guen
Mada Ghanem
Camille Taillé
Clairelyne Dupin
Philippe Dieudé
Caroline Kannengiesser
Bruno Crestani
Source :
European Respiratory Review, Vol 28, Iss 153 (2019)
Publication Year :
2019
Publisher :
European Respiratory Society, 2019.

Abstract

Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.

Details

Language :
English
ISSN :
09059180 and 16000617
Volume :
28
Issue :
153
Database :
Directory of Open Access Journals
Journal :
European Respiratory Review
Publication Type :
Academic Journal
Accession number :
edsdoj.64c028a3a56a465c929ce9fc75750217
Document Type :
article
Full Text :
https://doi.org/10.1183/16000617.0053-2019