Back to Search
Start Over
The genetics of interstitial lung diseases
- Source :
- European Respiratory Review, Vol 28, Iss 153 (2019)
- Publication Year :
- 2019
- Publisher :
- European Respiratory Society, 2019.
-
Abstract
- Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough, abnormalities in gas exchange, restrictive physiology (characterised by decreased lung volumes), hypoxaemia and, if progressive, respiratory failure. In some cases, ILDs can be caused by systemic diseases or environmental exposures. The ability to treat or cure these ILDs varies based on the subtype and in many cases lung transplantation remains the only curative therapy. There is a growing body of evidence that both common and rare genetic variants contribute to the development and clinical manifestation of many of the ILDs. Here, we review the current understanding of genetic risk and ILD.
- Subjects :
- Diseases of the respiratory system
RC705-779
Subjects
Details
- Language :
- English
- ISSN :
- 09059180 and 16000617
- Volume :
- 28
- Issue :
- 153
- Database :
- Directory of Open Access Journals
- Journal :
- European Respiratory Review
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.64c028a3a56a465c929ce9fc75750217
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/16000617.0053-2019