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Regulation of GH and GH Signaling by Nutrients

Authors :
Marina Caputo
Stella Pigni
Emanuela Agosti
Tommaso Daffara
Alice Ferrero
Nicoletta Filigheddu
Flavia Prodam
Source :
Cells, Vol 10, Iss 6, p 1376 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with important roles in lifespan. They promote growth, anabolic actions, and body maintenance, and in conditions of energy deprivation, favor catabolic feedback mechanisms switching from carbohydrate oxidation to lipolysis, with the aim to preserve protein storages and survival. IGF-I/insulin signaling was also the first one identified in the regulation of lifespan in relation to the nutrient-sensing. Indeed, nutrients are crucial modifiers of the GH/IGF-I axis, and these hormones also regulate the complex orchestration of utilization of nutrients in cell and tissues. The aim of this review is to summarize current knowledge on the reciprocal feedback among the GH/IGF-I axis, macro and micronutrients, and dietary regimens, including caloric restriction. Expanding the depth of information on this topic could open perspectives in nutrition management, prevention, and treatment of GH/IGF-I deficiency or excess during life.

Details

Language :
English
ISSN :
20734409
Volume :
10
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.64ebcb71cca54e9095685dbfade67883
Document Type :
article
Full Text :
https://doi.org/10.3390/cells10061376