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Liquid biopsy detects genomic drivers in NSCLC without EGFR mutations by single‐plex testing: WJOG13620L

Liquid biopsy detects genomic drivers in NSCLC without EGFR mutations by single‐plex testing: WJOG13620L

Authors :
Takehiro Uemura
Hirotsugu Kenmotsu
Daisuke Hazama
Shunsuke Teraoka
Hiroshi Kobe
Koichi Azuma
Teppei Yamaguchi
Takeshi Masuda
Toshihide Yokoyama
Kohei Otsubo
Koji Haratani
Daisuke Hayakawa
Masahide Oki
Shinnosuke Takemoto
Tomohiro Ozaki
Yusaku Akashi
Akito Hata
Hiroya Hashimoto
Nobuyuki Yamamoto
Kazuhiko Nakagawa
Source :
Cancer Medicine, Vol 12, Iss 23, Pp 21097-21110 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Background Actionable tumor genomic alterations, primarily EGFR mutations, occur in nearly 70% of Japanese advanced nonsquamous non‐small cell lung cancer (NSCLC) patients. Standard assessment of tumor tissue includes rapid testing for EGFR mutations, ALK fusions and ROS1 fusions. We conducted a prospective observational study (WJOG13620L) of follow‐on next‐generation sequencing of circulating tumor DNA (ctDNA) in patients without driver alterations after EGFR testing. Methods Patients with untreated advanced (Stage IIIB–IV or relapsed) nonsquamous NSCLC without EGFR mutations according to single‐plex testing of tumor tissue, were enrolled into this study. Patients with other known driver mutations or who underwent comprehensive genomic profiling were excluded. Plasma was analyzed by Guardant360, and the primary endpoint was the proportion of patients with pathogenic gene alterations in at least one of nine genes. Results Among the 72 patients enrolled, ALK and ROS1 fusions were tested in 86.1% and 65.2%, respectively. Alterations in pre‐defined genes were detected in 21 patients (29.2%; 95% confidence interval: 19.0–41.1, p

Details

Language :
English
ISSN :
20457634
Volume :
12
Issue :
23
Database :
Directory of Open Access Journals
Journal :
Cancer Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.653a72701e5d487b855668fed38c1519
Document Type :
article
Full Text :
https://doi.org/10.1002/cam4.6668