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RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy

Authors :
Jing Zhang
Bin Wang
Xiaoxiao Gao
Cheng Peng
Chao Shan
Silas F. Johnson
Richard C. Schwartz
Yong-Hui Zheng
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Little is known about how proteostasis is maintained during viral infection. Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.65b909852c47fabd4f56d608918dcc
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33805-9