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Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

Authors :
Angela Di Cesare
Simone Morelli
Giulia Morganti
Giulia Simonato
Fabrizia Veronesi
Mariasole Colombo
Michele Berlanda
Wilfried Lebon
Matilde Gallo
Frederic Beugnet
Donato Traversa
Source :
Parasites & Vectors, Vol 14, Iss 1, Pp 1-6 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Capillaria aerophila and Capillaria boehmi parasitize the respiratory system of wild and domestic carnivores. Capillaria aerophila inhabits the trachea and bronchi of dogs and cats, while C. boehmi affects the nasal cavities and sinuses of dogs. In dogs the infection may be subclinical or characterized by varying respiratory distress. Methods The present study evaluated the efficacy of an oral formulation containing milbemycin oxime and afoxolaner (NEXGARD SPECTRA®) in dogs naturally infected with C. aerophila and/or C. boehmi from three enzootic areas of Italy. Dogs were enrolled pending fecal examination and molecular confirmation of respiratory capillarioses. Dogs were allocated in two groups: Group 1 (G1, 25 dogs), treated with a negative control product with no anthelmintic activity (afoxolaner, NEXGARD®), and Group 2 (G2, 26 dogs), treated with NEXGARD SPECTRA®. At the day of treatment administration (Day 0), all dogs were clinically examined. Dogs were again subjected to clinical and fecal examinations at Days 28 (± 4) and 56 (± 2). The primary criterion for treatment efficacy was the reduction of fecal Capillaria egg counts in G2 compared with G1. The regression of/recovery from baseline clinical signs was considered as a further efficacy criterion. Results Percentage reduction of fecal Capillaria egg counts in the NEXGARD SPECTRA® group compared to the control group was > 97% on Day 28 and 100% on Day 56, respectively (p

Details

Language :
English
ISSN :
17563305
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Parasites & Vectors
Publication Type :
Academic Journal
Accession number :
edsdoj.65f69e0bb60d4faa9153313615744513
Document Type :
article
Full Text :
https://doi.org/10.1186/s13071-021-04648-y