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MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression

Authors :
Xianjin Du
Miao Wu
Dan Tian
Jianlin Zhou
Lu Wang
Liying Zhan
Source :
PPAR Research, Vol 2020 (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

The severity of sepsis may be associated with excessive inflammation, thus leading to acute liver injury. MicroRNA-21 is highly expressed in the liver of a variety of inflammation-related diseases, and PPARα is also proved to participate in regulating inflammation. In the present study, the LPS-induced sepsis model was established. We found that microRNA-21 expression was upregulated in the liver of sepsis mice, and microRNA-21 inhibition significantly reduced the liver injury. The expression of liver injury markers, inflammation cytokines, and PPARα in the septic mice was higher than in antagomir-21 treated septic mice. In addition, we also found that PPARα is the target gene of microRNA-21; PPARα antagonist GW6471 could reverse the effect of antagomir-21. In conclusion, our study illustrated that microRNA-21 exacerbate acute liver injury in sepsis mice by inhibiting PPARα expression.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
16874757 and 16874765
Volume :
2020
Database :
Directory of Open Access Journals
Journal :
PPAR Research
Publication Type :
Academic Journal
Accession number :
edsdoj.6608bcf3fd01451bad741440aeec21d1
Document Type :
article
Full Text :
https://doi.org/10.1155/2020/6633022