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Prevalence of Histoplasmosis among Persons with Advanced HIV Disease, Nigeria
- Source :
- Emerging Infectious Diseases, Vol 28, Iss 11, Pp 2261-2269 (2022)
- Publication Year :
- 2022
- Publisher :
- Centers for Disease Control and Prevention, 2022.
-
Abstract
- We sought to determine the prevalence of probable disseminated histoplasmosis among advanced HIV disease (AHD) patients in Nigeria. We conducted a cross-sectional study in 10 sites across 5 of 6 geopolitical zones in Nigeria. We identified patients with urinary samples containing CD4 cell counts 2 clinical features of disseminated histoplasmosis, and we tested them for Histoplasma antigen using a Histoplasma enzyme immune assay. Of 988 participants we recruited, 76 (7.7%) were antigen-positive. The 76 Histoplasma antigen–positive participants had significantly lower (p = 0.03) CD4 counts; 9 (11.8%) were also co-infected with tuberculosis. Most antigen-positive participants (50/76; 65.8%; p = 0.015) had previously received antiretroviral treatment; 26/76 (34.2%) had not. Because histoplasmosis is often a hidden disease among AHD patients in Nigeria, Histoplasma antigen testing should be required in the AHD package of care.
Details
- Language :
- English
- ISSN :
- 10806040 and 10806059
- Volume :
- 28
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.660e001a622548b49147ee22ac7d57a1
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2811.220542