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Serrated Polyps and Their Alternative Pathway to the Colorectal Cancer: A Systematic Review

Authors :
Łukasz Szylberg
Marlena Janiczek
Aneta Popiel
Andrzej Marszałek
Source :
Gastroenterology Research and Practice, Vol 2015 (2015)
Publication Year :
2015
Publisher :
Hindawi Limited, 2015.

Abstract

Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. For a long time, only one pathway of colorectal carcinogenesis was known. In recent years, a new “alternative” pathway through serrated adenoma was described. Recent meta-analysis estimated these cancers as about 10% to 30% of all CRCs. Serrated polyps are the second most popular groups of polyps (after conventional adenomas) found during colonoscopy. Serrated polyps of the colon are clinically and molecularly diverse changes that have common feature as crypt luminal morphology characterized by glandular serration. Evidence suggests that subtypes of serrated polyps, particularly TSA and SSA/P, can lead to adenocarcinoma through the serrated pathway. Moreover, the data indicate that the SSA/P are the precursors of colorectal carcinoma by MSI and may be subject to rapid progression to malignancy. An important step to reduce the incidence of CRC initiated by the serrated pathway is to improve the detection of serrated polyps and to ensure their complete removal during endoscopy. Understanding of the so-called serrated carcinogenesis pathway is an important step forward in expanding possibilities in the prevention of CRC.

Details

Language :
English
ISSN :
16876121 and 1687630X
Volume :
2015
Database :
Directory of Open Access Journals
Journal :
Gastroenterology Research and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.6695c759564734b3f4d10b533c786e
Document Type :
article
Full Text :
https://doi.org/10.1155/2015/573814