Back to Search Start Over

The use of late preterm antenatal corticosteroids in women with gestational diabetes : a puzzle worth solving

The use of late preterm antenatal corticosteroids in women with gestational diabetes : a puzzle worth solving

Authors :
Sadullah Özkan
Murat Levent Dereli
Dilara Kurt
Ahmet Kurt
Sadun Sucu
Fahri Burçin Fıratlıgil
Fatih İşleyen
Şevki Çelen
Yaprak Engin Üstün
Source :
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-7 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background To investigate the association between late preterm antenatal corticosteroid treatment and outcome in late preterm neonates born to mothers with gestational diabetes mellitus, Methods All patients with gestational diabetes mellitus who had a late preterm delivery at Etlik Lady Zübeyde Hospital between 2017 and 2021 were included. Women who met the inclusion criteria and were not given antenatal corticosteroid treatment during current pregnancy before 34 0/7 weeks of gestation were divided into two groups according to whether or not they received late preterm antenatal corticosteroid treatment. The two groups were compared in terms of adverse neonatal complications. The main outcomes were composite respiratory outcome and composite neonatal outcome. Logistic regression analysis was used to determine additional potential predictors of neonatal outcome. Results This retrospective cohort study included a total of 400 participants with gestational diabetes mellitus who had a late preterm delivery within the study period. Of these women, 196 (49%) received late preterm antenatal corticosteroid treatment. Main outcomes showed no difference. Decreasing gestational age at birth was identified as an independent risk factor predicting both composite respiratory outcome and composite neonatal outcome in multivariate logistic regression analysis. Conclusions Antenatal corticosteroid treatment at or after 34 0/7 weeks of gestation in women with gestational diabetes mellitus who had a late preterm delivery was not associated with improvement in adverse neonatal outcomes. Decreasing gestational age at birth was the only independent risk factor predicting composite neonatal and composite respiratory outcomes.

Details

Language :
English
ISSN :
14712393
Volume :
24
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Pregnancy and Childbirth
Publication Type :
Academic Journal
Accession number :
edsdoj.66975819870a4acb93fa846e9d29ade8
Document Type :
article
Full Text :
https://doi.org/10.1186/s12884-024-06510-2