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The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

Authors :
Robert Verity
Ozkan Aydemir
Nicholas F. Brazeau
Oliver J. Watson
Nicholas J. Hathaway
Melchior Kashamuka Mwandagalirwa
Patrick W. Marsh
Kyaw Thwai
Travis Fulton
Madeline Denton
Andrew P. Morgan
Jonathan B. Parr
Patrick K. Tumwebaze
Melissa Conrad
Philip J. Rosenthal
Deus S. Ishengoma
Jeremiah Ngondi
Julie Gutman
Modest Mulenga
Douglas E. Norris
William J. Moss
Benedicta A. Mensah
James L. Myers-Hansen
Anita Ghansah
Antoinette K. Tshefu
Azra C. Ghani
Steven R. Meshnick
Jeffrey A. Bailey
Jonathan J. Juliano
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 25184741
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.66be251847414c22986caeb0cfc8324e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15779-8