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Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

Authors :
Yuya Ide, MD
Takahiro Horie, MD, PhD
Naritatsu Saito, MD, PhD
Shin Watanabe, MD, PhD
Chiharu Otani, MD
Yui Miyasaka, BSc
Yasuhide Kuwabara, MD, PhD
Tomohiro Nishino, MD, PhD
Tetsushi Nakao, MD, PhD
Masataka Nishiga, MD, PhD
Hitoo Nishi, MD, PhD
Yasuhiro Nakashima, MD, PhD
Fumiko Nakazeki, MD, PhD
Satoshi Koyama, MD, PhD
Masahiro Kimura, MD
Shuhei Tsuji, MD
Randolph Ruiz Rodriguez, MD
Sijia Xu, MD
Tomohiro Yamasaki, MD
Toshimitsu Watanabe, MD
Masamichi Yamamoto, PhD
Motoko Yanagita, MD, PhD
Takeshi Kimura, MD, PhD
Akira Kakizuka, MD, PhD
Koh Ono, MD, PhD
Source :
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Summary: No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention. Key Words: ATP, ER stress, KUS121, myocardial infarction

Subjects

Subjects :
Diseases of the circulatory (Cardiovascular) system
RC666-701

Details

Language :
English
ISSN :
2452302X
Volume :
4
Issue :
6
Database :
Directory of Open Access Journals
Journal :
JACC: Basic to Translational Science
Publication Type :
Academic Journal
Accession number :
edsdoj.66cbcb274f6484fb40460d224a0132a
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jacbts.2019.06.001
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