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Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at these contact sites.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.670432a918664d32a912916b09eded29
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-18413-9