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Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

Authors :
Yifei Miao
Nassim E. Ajami
Tse-Shun Huang
Feng-Mao Lin
Chih-Hong Lou
Yun-Ting Wang
Shuai Li
Jian Kang
Hannah Munkacsi
Mano R. Maurya
Shakti Gupta
Shu Chien
Shankar Subramaniam
Zhen Chen
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

eNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.67095a0978f4a1bbc2ae67affad3970
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-02113-y