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Polymeric Microneedle Drug Delivery Systems: Mechanisms of Treatment, Material Properties, and Clinical Applications—A Comprehensive Review

Authors :
Yun Liu
Ruiyue Mao
Shijia Han
Zhi Yu
Bin Xu
Tiancheng Xu
Source :
Polymers, Vol 16, Iss 18, p 2568 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their transformative potential in the realm of transdermal drug administration. Our scrutiny centers on the substrate materials pivotal for microneedle construction and the core properties that dictate their efficacy. We delve into the distinctive interplay between microneedles and dermal layers, underscoring the mechanisms by which this synergy enhances drug absorption and precision targeting. Moreover, we examine the acupoint–target organ–ganglion nexus, an innovative strategy that steers drug concentration to specific targets, offering a paradigm for precision medicine. A thorough analysis of the clinical applications of polymeric microneedle systems is presented, highlighting their adaptability and impact across a spectrum of therapeutic domains. This review also accentuates the systems’ promise to bolster patient compliance, attributed to their minimally invasive and painless mode of drug delivery. We present forward-looking strategies aimed at optimizing stimulation sites to amplify therapeutic benefits. The anticipation is set for the introduction of superior biocompatible materials with advanced mechanical properties, customizing microneedles to cater to specialized clinical demands. In parallel, we deliberate on safety strategies aimed at boosting drug loading capacities and solidifying the efficacy of microneedle-based therapeutics. In summation, this review accentuates the pivotal role of polymeric microneedle technology in contemporary healthcare, charting a course for future investigative endeavors and developmental strides within this burgeoning field.

Details

Language :
English
ISSN :
20734360
Volume :
16
Issue :
18
Database :
Directory of Open Access Journals
Journal :
Polymers
Publication Type :
Academic Journal
Accession number :
edsdoj.67205b2333e140fe952cd02009d4e887
Document Type :
article
Full Text :
https://doi.org/10.3390/polym16182568