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JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

Authors :
Matthew Wong
Yuting Sun
Zhichao Xi
Giorgio Milazzo
Rebecca C. Poulos
Christoph Bartenhagen
Jessica L. Bell
Chelsea Mayoh
Nicholas Ho
Andrew E. Tee
Xiaoqiong Chen
Yang Li
Roberto Ciaccio
Pei Y. Liu
Chen C. Jiang
Qing Lan
Nisitha Jayatilleke
Belamy B. Cheung
Michelle Haber
Murray D. Norris
Xu D. Zhang
Glenn M. Marshall
Jenny Y. Wang
Stefan Hüttelmaier
Matthias Fischer
Jason W. H. Wong
Hongxi Xu
Giovanni Perini
Qihan Dong
Rani E. George
Tao Liu
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorigenic factor.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.673d07528164588b51a22500785ed47
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11132-w