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Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

Authors :
Giuseppe Angelico
Stefano Marletta
Giuseppe Broggi
Paolo Vigneri
Giada Maria Vecchio
Lucia Salvatorelli
Gaetano Magro
Source :
Diagnostics, Vol 12, Iss 2, p 357 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cellular angiofibroma (CAF), angiomyofibroblastoma (AMFB) or myofibroblastoma (MFB). Despite the differential diagnosis between these entities being usually straightforward, their increasingly recognized unusual morphological variants, along with the overlapping morphological and immunohistochemical features among these tumours, may raise serious differential diagnostic problems. Methods and Results: The data presented in the present paper have been retrieved from the entire published literature on the PubMed website about DAM, CAF, AFMB and MFB from 1984 to 2021. The selected articles are mainly represented by small-series, and, more rarely, single-case reports with unusual clinicopathologic features. The present review focuses on the diagnostic clues of the stromal tumours of the lower female genital tract to achieve a correct classification. The main clinicopathologic features of each single entity, emphasizing their differential diagnostic clues, are discussed and summarized in tables. Representative illustrations, including the unusual morphological variants, of each single tumour are also provided. Conclusion: Awareness by pathologists of the wide morphological and immunohistochemical spectrum exhibited by these tumours is crucial to achieve correct diagnoses and to avoid confusion with reactive conditions or other benign or malignant entities.

Details

Language :
English
ISSN :
20754418
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.6781bdbf9424d3ca2763f629415912b
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics12020357