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ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference
- Source :
- Molecular & Cellular Oncology, Vol 8, Iss 5 (2021)
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- By exploiting an integrated experimental platform based on patient-derived cancer stem cells, we identified a glioblastoma subset characterized by inheritable Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) overexpression, metabolic dependency on ERBB3 signaling, and liability to ERBB3 targeting. We provide insights on why some glioblastomas may rely on ERBB3 and how to recognize them.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 8
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.67ebfe84b8b74f16b4604c50f311233d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2021.1990677