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Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

Authors :
Fiona A. Hagenbeek
Jenny van Dongen
René Pool
Amy C. Harms
Peter J. Roetman
Vassilios Fanos
Britt J. van Keulen
Brian R. Walker
Naama Karu
Hilleke E. Hulshoff Pol
Joost Rotteveel
Martijn J. J. Finken
Robert R. J. M. Vermeiren
Cornelis Kluft
Meike Bartels
Thomas Hankemeier
Dorret I. Boomsma
Source :
Metabolites, Vol 12, Iss 6, p 474 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7–12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25–0.64), 0.50 (range: 0.33–0.62), and 0.64 (range: 0.43–0.81), respectively. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37–0.68), 0.50 (range; 0.23–0.61), and 0.47 (range: 0.32–0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones.

Details

Language :
English
ISSN :
22181989
Volume :
12
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.688ad8fdf81a452d979a3e4613da6de5
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo12060474