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Innovative gelatin-based micelles with AS1411 aptamer targeting and reduction responsiveness for doxorubicin delivery in tumor therapy

Authors :
Jingmou Yu
Yifei Zhang
Meilin Xu
Dengzhao Jiang
Wenbo Liu
Hongguang Jin
Pu Chen
Jing Xu
Lei Zhang
Source :
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116446- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Herein, we constructed innovative reduction-sensitive and targeted gelatin-based micelles for doxorubicin (DOX) delivery in tumor therapy. AS1411 aptamer-modified gelatin-ss-tocopherol succinate (AGSST) and the control GSST without AS1411 modification were synthesized and characterized. Antitumor drug DOX-containing AGSST (AGSST-D) and GSST-D nanoparticles were prepared, and their shapes were almost spherical. Reduction-responsive characteristics of DOX release in vitro were revealed in AGSST-D and GSST-D. Compared with non-targeted GSST-D, AGSST-D demonstrated better intracellular uptake and stronger cytotoxicity against nucleolin-overexpressed A549 cells. Importantly, AGSST-D micelles showed more effective killing activity in A549-bearing mice than GSST-D and DOX⋅HCl. It was revealed that AGSST-D micelles had no obvious systemic toxicity. Overall, AGSST micelles would have the potential to be an effective drug carrier for targeted tumor therapy.

Details

Language :
English
ISSN :
07533322
Volume :
174
Issue :
116446-
Database :
Directory of Open Access Journals
Journal :
Biomedicine & Pharmacotherapy
Publication Type :
Academic Journal
Accession number :
edsdoj.68a56d0c3be54d9c87241a3b57c64ae1
Document Type :
article
Full Text :
https://doi.org/10.1016/j.biopha.2024.116446