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Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms
- Source :
- Stem Cells International, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.
- Subjects :
- Internal medicine
RC31-1245
Subjects
Details
- Language :
- English
- ISSN :
- 1687966X and 16879678
- Volume :
- 2015
- Database :
- Directory of Open Access Journals
- Journal :
- Stem Cells International
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.68be89e2762546a4a4b10072c43c256f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2015/434962