Alternatives options to improve integrated treatment of trophic ulcers of venous etiology and assessment of its effectiveness

Objective: to improve the results of complex treatment of patients with trophic venous ulcers of the lower extremities by developing and introducing new methods of pharmacotherapy with morphological, immunohistochemical and biochemical evaluation of the reparative processes. Materials and methods: 72 patients with chronic venous insuffi ciency of C6 class under CEAP, in two clinical groups, underwent complex treatment and morphological features of trophic ulcers biopsies and monitoring of neopterin level were prospectively studied. In both groups, multicomponent antibacterial water-soluble ointments were used for topical treatment, which was supplemented with compression therapy and use of phlebotonics. Th e fi rst group consisted of 52 patients who additionally received magnesium orotate and enterosorption with dioctahedral smectite in the complex treatment of trophic ulcers, and the second group included 20 patients who did not receive the proposed additional therapy. Results: The effectiveness of the combined use of magnesium preparations and enterosorption has been proved. Conclusion: Th e inclusion of preparations of organic magnesium and enterosorption in complex treatment of trophic ulcers of venous etilogy allows the accleration of the healing process and shorten the period of stay of patients in the hospital.