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Sodium-glucose co-transporter-2 inhibitor-associated non-diabetic ketoacidosis: a case report

Authors :
Vincenzo Trapanese
Francesco Maruca
Maria Resilde Natale
Federica Giofrè
Francesca Cosentino
Silvia Sergi
Giuseppe Armentaro
Valentino Condoleo
Franco Arturi
Source :
Italian Journal of Medicine, Vol 18, Iss 2 (2024)
Publication Year :
2024
Publisher :
PAGEPress Publications, 2024.

Abstract

Ketoacidosis is considered an emergency metabolic disorder that can be triggered by starvation and alcohol consumption in addition to diabetes. We described an unusual case of ketoacidosis in a non-diabetic young man who presented to our hospital with a complaint of rapid and shallow breathing, weakness and nausea. Fourteen days back, due to heart failure, he started sodiumglucose co-transporter 2 inhibitors (SGLT2-i) in addition to fumarate bisoprolol, sacubitril/valsartan and eplerenone. Based on clinical examination, ketoacidosis was suspected, although his glucose and glycosylated hemoglobin levels were in range. Overall, based on the clinical and laboratory findings, the diagnosis of euglycemic non-diabetic ketoacidosis due to the use of the SGLT2- i was made and SGLT2-i has been discontinued. Although SGLT2-i are effective and safe drugs, it is advisable to carefully evaluate their use also in non-diabetic patients especially when hepatic fibrosis or incorrect eating habits are present.

Details

Language :
English
ISSN :
18779344 and 18779352
Volume :
18
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Italian Journal of Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.694667194d824686a1f946aebe839a73
Document Type :
article
Full Text :
https://doi.org/10.4081/itjm.2024.1716