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A pediatric case of productive cough caused by novel variants in DNAH9

Authors :
Kazuhiko Takeuchi
Yifei Xu
Satoru Ogawa
Makoto Ikejiri
Kaname Nakatani
Shimpei Gotoh
Satoko Usui
Sawako Masuda
Mizuho Nagao
Takao Fujisawa
Source :
Human Genome Variation, Vol 8, Iss 1, Pp 1-3 (2021)
Publication Year :
2021
Publisher :
Nature Publishing Group, 2021.

Abstract

Abstract We report the first Japanese case of primary ciliary dyskinesia caused by DNAH9 variations. The patient, a 5-year-old girl, had repeated episodes of productive cough after contracting the common cold at the age of 1 year and 6 months. She did not have a situs abnormality or congenital heart defect. We identified two novel DNAH9 variants, NM_001372.3: c. [1298C>G];[5547_5550delTGAC], (p.[Ser433Cys];[Asp1850fs]).

Subjects

Subjects :
Genetics
QH426-470
Life
QH501-531

Details

Language :
English
ISSN :
2054345X
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Human Genome Variation
Publication Type :
Academic Journal
Accession number :
edsdoj.694c8e7bf4d2482db6f3d3c519609cf4
Document Type :
article
Full Text :
https://doi.org/10.1038/s41439-020-00134-6