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Venous Outflow Profiles Are Linked to Clinical Outcomes in Ischemic Stroke Patients with Extensive Baseline Infarct
- Source :
- Journal of Stroke, Vol 24, Iss 3, Pp 372-382 (2022)
- Publication Year :
- 2022
- Publisher :
- Korean Stroke Society, 2022.
-
Abstract
- Background and Purpose The benefit of endovascular thrombectomy (EVT) treatment is still unclear in stroke patients presenting with extensive baseline infarct. The use of additional imaging biomarkers could improve clinical outcome prediction and individualized EVT selection in this vulnerable cohort. We hypothesized that cerebral venous outflow (VO) may be associated with functional outcomes in patients with low Alberta Stroke Program Early CT Score (ASPECTS). Methods We conducted a retrospective multicenter cohort study of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Extensive baseline infarct was defined by an ASPECTS of ≤5 on admission computed tomography (CT). VO profiles were assessed on admission CT angiography using the Cortical Vein Opacification Score (COVES). Favorable VO was defined as COVES ≥3. Multivariable logistic regression was used to determine the association between cerebral VO and good clinical outcomes (90-day modified Rankin Scale score of ≤3). Results A total of 98 patients met the inclusion criteria. Patients with extensive baseline infarct and favorable VO achieved significantly more often good clinical outcomes compared to patients with unfavorable VO (45.5% vs. 10.5%, P
Details
- Language :
- English
- ISSN :
- 22876391 and 22876405
- Volume :
- 24
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Stroke
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.696eb157c8334d97be3324f12bd56ae5
- Document Type :
- article
- Full Text :
- https://doi.org/10.5853/jos.2022.01046