PREVALENCE OF CARBAPENEM RESISTANT ENTEROBACTERIACEAE IN GWALIOR REGION IN BLOOD CULTURE ISOLATES

Introduction: Carbapenems are broad spectrum β Lactam antibiotics & are the last resort to control infections caused by gram negative bacteria. The increasing resistance to these antibiotics is an alarming sign. CRE (Carbapenem resistant Enterobacteriaceae) is reported due to acquisition of carbapenemase genes or association with decreased outer membrane permeability with β lactamases with weak carbapenemase activity. Methods: Total 123 culture positive blood samples from our tertiary care hospital were included in which carbapenem resistance was identified and the resistant strains were assessed for carbapenemase production by Modified Hodge Test (MHT) & Modified Carbapenemase inactivation method (mCIM) simultaneously. Results: Out of total 896 blood samples received, 123 isolates were members of Enterobacteriaceae family. The maximum isolates were Escherichia coli 39(31.70%) next was Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiella aerogenes, Citrobacter freundii. Carbapenem resistance was seen in 19(15.44%) isolates. The positivity rate by MHT was 11 (57.89%) while by mCIM was 17(89.47%). Conclusion: Prevalence of carbapenem resistance was 15.44%.