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Insulin metabolism markers are predictors of subclinical atherosclerosis among overweight and obese children and adolescents
- Source :
- BMC Pediatrics, Vol 18, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Abstract Background To investigate the association between markers of insulin metabolism and carotid intima-media thickness(cIMT) among overweight and obese children and adolescents. Methods A total of 378 children and adolescents aged from 6 to 13 years, with WHO body mass index Z-Scores ≥2 were enrolled in this study. We measured fasting serum insulin and glucose, conducted a homeostatic model assessment of insulin resistance(HOMA-IR), and calculated the quantitative insulin sensitivity check index(QUICKI). Carotid intima-media thickness was measured in the common carotid artery with high-resolution ultrasonography. Results The study participants consisted of 198 boys and 180 girls with a mean(±SD) age of 9.3 ± 1.7 years, 18.3% being pre-pubertal. In boys, after controlling for confounders, a one-SD increase in fasting insulin and HOMA-IR were associated with 0.351 mm(P
- Subjects :
- Insulin resistance
Atherosclerosis
Children
Adolescents, obesity
Pediatrics
RJ1-570
Subjects
Details
- Language :
- English
- ISSN :
- 14712431
- Volume :
- 18
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6a07035ff3284de586b58f293866ab46
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12887-018-1347-9