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Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6a0a59accc9488fa4d118ffc7d1f1f9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11745-1