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Pleiotropic Effects of IGF1 on the Oocyte

Authors :
Paweł Kordowitzki
Kornelia Krajnik
Agnieszka Skowronska
Mariusz T. Skowronski
Source :
Cells, Vol 11, Iss 10, p 1610 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

A woman’s endocrine system plays a crucial role in orchestrating cellular interactions throughout her life. The growth hormone (GH) and insulin-like growth factor (IGF) system appears to impact crucial reproductive events and cell types of the ovary, such as granulosa cells, theca cells, and oocytes. Further, IGF1 is a cornerstone during embryonic development and influences predominantly developing and pre-antral follicles. In this commentary, we will emphasize the pleiotropic effects of IGF1 on physiological processes inside the egg. Herein, we will provide a brief overview on IGF1 related cell signal transduction pathways during the maturation and aging of oocytes. We aim to elucidate from a molecular and biochemical point of view if IGF1 in women with metabolic imbalances such as obesity or diabetes could be used in clinics as a novel, reliable estimator for the developmental competence of an oocyte.

Details

Language :
English
ISSN :
20734409
Volume :
11
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.6a22c22c51ae49cbb902d8288c1155aa
Document Type :
article
Full Text :
https://doi.org/10.3390/cells11101610