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Gut microbiota: a new insight into neurological diseases

Authors :
Lanxiang Liu
Haiyang Wang
Xueyi Chen
Peng Xie
Ting Gao
Xiuyuan Hao
Source :
Chinese Medical Journal, Vol 136, Iss 11, Pp 1261-1277 (2023)
Publication Year :
2023
Publisher :
Wolters Kluwer, 2023.

Abstract

Abstract. In the last decade, it has become increasingly recognized that a balanced gut microbiota plays an important role in maintaining the health of the host. Numerous clinical and preclinical studies have shown that changes in gut microbiota composition are associated with a variety of neurological diseases, e.g., Parkinson's disease, Alzheimer's disease, and myasthenia gravis. However, the underlying molecular mechanisms are complex and remain unclear. Behavioral phenotypes can be transmitted from humans to animals through gut microbiota transplantation, indicating that the gut microbiota may be an important regulator of neurological diseases. However, further research is required to determine whether animal-based findings can be extended to humans and to elucidate the relevant potential mechanisms by which the gut microbiota regulates neurological diseases. Such investigations may aid in the development of new microbiota-based strategies for diagnosis and treatment and improve the clinical management of neurological disorders. In this review, we describe the dysbiosis of gut microbiota and the corresponding mechanisms in common neurological diseases, and discuss the potential roles that the intestinal microbiome may play in the diagnosis and treatment of neurological disorders.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
03666999, 25425641, and 00000000
Volume :
136
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Chinese Medical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.6a8b534772384bcbbdc9f79495637ca4
Document Type :
article
Full Text :
https://doi.org/10.1097/CM9.0000000000002212