Back to Search Start Over

Continuous Glucose Monitoring in Hypoxic Environments Based on Water Splitting-Assisted Electrocatalysis

Authors :
Lanjie Lei
Chengtao Xu
Xing Dong
Biao Ma
Yichen Chen
Qing Hao
Chao Zhao
Hong Liu
Source :
Chemosensors, Vol 11, Iss 2, p 149 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Conventional enzyme-based continuous glucose sensors in interstitial fluid usually rely on dissolved oxygen as the electron-transfer mediator to bring electrons from oxidase to electrode while generating hydrogen peroxide. This may lead to several problems. First, the sensor may provide biased detection results owing to fluctuation of oxygen in interstitial fluid. Second, the polymer coatings that regulate the glucose/oxygen ratio can affect the dynamic response of the sensor. Third, the glucose oxidation reaction continuously produces corrosive hydrogen peroxide, which may compromise the long-term stability of the sensor. Here, we introduce an oxygen-independent nonenzymatic glucose sensor based on water splitting-assisted electrocatalysis for continuous glucose monitoring. For the water splitting reaction (i.e., hydrogen evolution reaction), a negative pretreatment potential is applied to produce a localized alkaline condition at the surface of the working electrode for subsequent nonenzymatic electrocatalytic oxidation of glucose. The reaction process does not require the participation of oxygen; therefore, the problems caused by oxygen can be avoided. The nonenzymatic sensor exhibits acceptable sensitivity, reliability, and biocompatibility for continuous glucose monitoring in hypoxic environments, as shown by the in vitro and in vivo measurements. Therefore, we believe that it is a promising technique for continuous glucose monitoring, especially for clinically hypoxic patients.

Details

Language :
English
ISSN :
22279040
Volume :
11
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Chemosensors
Publication Type :
Academic Journal
Accession number :
edsdoj.6a8e1d233b81475a998e0b76b8f42b0b
Document Type :
article
Full Text :
https://doi.org/10.3390/chemosensors11020149