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Epidemiology of metabolic syndrome and its components in Chinese patients with a range of thyroid-stimulating hormone concentrations

Authors :
Kun Tang
Qiao Zhang
Nian-chun Peng
Miao Zhang
Shu-jing Xu
Hong Li
Ying Hu
Chun-ju Xue
Li-xin Shi
Source :
Journal of International Medical Research, Vol 48 (2020)
Publication Year :
2020
Publisher :
SAGE Publishing, 2020.

Abstract

Objective To investigate the relationship between thyroid stimulating hormone (TSH) concentration and the risks of developing metabolic syndrome and its components. Methods A total of 10,140 residents of the Yunyan district of Guiyang (Guizhou, China) who were ≥40 years old were selected by cluster random sampling between May and August 2011, of whom 5692 were eligible. TSH concentration and indices of metabolic syndrome were documented at baseline and 3 years later. Participants were allocated to a euthyroid (TSH 0.55–4.78 mIU/L) or high TSH concentration (TSH >4.78 mIU/L) group. Patients with overt hypothyroidism or were undergoing treatment for hypothyroidism were excluded. Results The crude and adjusted prevalences of metabolic syndrome were 39.9% and 33.9% in the euthyroid group and 44.3% and 37.5% in the high TSH group, respectively. Binary logistic regression analysis revealed a positive correlation between a high TSH concentration at baseline and the cumulative incidence of metabolic syndrome during follow up. Conclusions High TSH is associated with a higher risk of developing metabolic syndrome or one of its components; therefore, people with a high TSH concentration should be screened regularly to permit the early identification of metabolic syndrome and followed up thoroughly.

Subjects

Subjects :
Medicine (General)
R5-920

Details

Language :
English
ISSN :
14732300 and 03000605
Volume :
48
Database :
Directory of Open Access Journals
Journal :
Journal of International Medical Research
Publication Type :
Academic Journal
Accession number :
edsdoj.6af4ccae0eff4f6185b28741baa5ff09
Document Type :
article
Full Text :
https://doi.org/10.1177/0300060520966878