Back to Search Start Over

Immunological imprinting of the antibody response in COVID-19 patients

Authors :
Teresa Aydillo
Alexander Rombauts
Daniel Stadlbauer
Sadaf Aslam
Gabriela Abelenda-Alonso
Alba Escalera
Fatima Amanat
Kaijun Jiang
Florian Krammer
Jordi Carratala
Adolfo García-Sastre
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

In addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the induction of specific antibodies against SARS-CoV-2.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6b17aeb12ca4e21a13051d57fbbeb62
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23977-1