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Progress in the study of intestinal microbiota involved in morphine tolerance

Authors :
Ke Bi
Yi Lei
Deshenyue Kong
Yuansen Li
Xuan Fan
Xiao Luo
Jiqun Yang
Guangqing Wang
Xuejun Li
Yu Xu
Huayou Luo
Source :
Heliyon, Vol 10, Iss 6, Pp e27187- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Morphine is a widely used opioid for treatment of pain. The attendant problems including morphine tolerance and morphine dependence pose a major public health challenge. In recent years, there has been increasing interest in the gastrointestinal microbiota in many physiological and pathophysiological processes. The connectivity network between the gut microbiota and the brain is involved in multiple biological systems, and bidirectional communication between them is critical in gastrointestinal tract homeostasis, the central nervous system, and the microbial system. Many research have previously shown that morphine has a variety of effects on the gastrointestinal tract, but none have determined the function of intestinal microbiota in morphine tolerance. This study reviewed the mechanisms of morphine tolerance from the perspective of dysregulation of microbiota-gut-brain axis homeostasis, by summarizing the possible mechanisms originating from the gut that may affect morphine tolerance and the improvement of morphine tolerance through the gut microbiota.

Details

Language :
English
ISSN :
24058440
Volume :
10
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.6b3cca746ad1484c8819c18fd23eb24c
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e27187