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Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy

Authors :
Agnes Koczo, MD
Amy Marino, MD
Arun Jeyabalan, MD
Uri Elkayam, MD
Leslie T. Cooper, MD
James Fett, MD, MPH
Joan Briller, MD
Eileen Hsich, MD
Lori Blauwet, MD
Charles McTiernan, PhD
Penelope A. Morel, MD
Karen Hanley-Yanez, BS
Dennis M. McNamara, MD, MS
Dennis M McNamara, MD
James D. Fett, MD
Jessica Pisarcik, RN, BSN
John Gorcsan, III, MD
Erik Schelbert, MD
Rami Alharethi, MD
Kismet Rasmusson, CRNP
Kim Brunisholz
Amy Butler, BS, CCRP
Deborah Budge
A.G. Kfoury, MD
Benjamin Horne, PhD
Joe Tuinei
Heather Brown
Julie Damp, MD
Allen J. Naftilan, MD
Jill Russell, RN, MSN
Darla Freehardt, LPN, BS, CCRP
Cynthia Oblak, CCRC
Greg Ewald, MD
Donna Whitehead, RN
Jean Flanagan, RN
Anne Platts
Jorge Caro, MPH
Stephanie Mullin, RN
Michael M. Givertz, MD
M. Susan Anello, RN, BS
Navin Rajagopalan, MD
David Booth, MD
Tiffany Sandlin, RN
Wendy Wijesiri, RN
Lori A. Blauwet, MD
Joann Brunner, RN
Mary Phelps
Ruth Kempf
Kalgi Modi, MD
Tracy Norwood
Decebal Sorin Griza, MD
G. Michael Felker, MD
Robb Kociol, MD
Patricia Adams, RN
Gretchen Wells, MD
Vinay Thohan, MD
Deborah Wesley-Farrington, RN, BSN, CCRC, CCA
Sandra Soots, RN, CCRC
Richard Sheppard, MD
Caroline Michel, MD
Nathalie Lapointe, RN, PhD
Heather Nathaniel
Angela Kealey, MD
Marc Semigran, MD
Maureen Daher, RN
John Boehmer, MD
David Silber, MD
Eric Popjes, MD
Patricia Frey, RN
Todd Nicklas, RN
Jeffrey Alexis, MD
Lori Caufield, RN, BSN, CCRC
John W. Thornton, III, MD
Mindy Gentry, MD
Vincent J.B. Robinson, MBBS
Gyanendra K. Sharma, MD
Joan Holloway, BS
Maria Powell, LPN, CCRC
David Markham, MD
Mark Drazner, MD
Lynn Fernandez, RN
Mark Zucker, MD
David A. Baran, MD
Martin L. Gimovsky, MD
Natalia Hochbaum, MD
Bharati Patel, RN, CCRC
Laura Adams, RN, BSN
Gautam Ramani, MD
Stephen Gottlieb, MD
Shawn Robinson, MD
Stacy Fisher, MD
Joanne Marshall, BSN, MS
Jennifer Haythe, MD
Donna Mancini, MD
Rachel Bijou, MD
Maryjane Farr, MD
Marybeth Marks
Henry Arango
Biykem Bozkurt, MD, PhD, FACC, FAHA
Mariana Bolos
Paul Mather, MD
Sharon Rubin, MD
Raphael Bonita, MD
Susan Eberwine, RN
Hal Skopicki, MD, PhD
Kathleen Stergiopoulos, MD
Ellen McCathy-Santoro, MD
Jennifer Intravaia, RN, CCRCII
Elizabeth Maas
Jordan Safirstein, MD
Audrey Kleet, RN, MS, ACNP-BC, CCRN, CCTC
Nancy Martinez, RN
Christine Corpoin, RN
Donna Hesari, RN
Sandra Chaparro, MD
Laura J. Hudson, MA, MPH, CCRC
Jalal K. Ghali, MD
Zora Injic, RN, BSc, MSA
Ilan S. Wittstein, MD
Source :
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 291-300 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Summary: The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8+ T cells. However, despite elevated prolactin and cytotoxic T cell subsets, myocardial recovery was not impaired in breastfeeding women. Key Words: breastfeeding, immune activation, peripartum cardiomyopathy

Subjects

Subjects :
Diseases of the circulatory (Cardiovascular) system
RC666-701

Details

Language :
English
ISSN :
2452302X
Volume :
4
Issue :
3
Database :
Directory of Open Access Journals
Journal :
JACC: Basic to Translational Science
Publication Type :
Academic Journal
Accession number :
edsdoj.6b537dab273b427cb490b11cb95baf93
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jacbts.2019.01.010
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