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Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

Authors :
Jeannette Abplanalp
Mario Leutert
Emilie Frugier
Kathrin Nowak
Roxane Feurer
Jiro Kato
Hans V. A. Kistemaker
Dmitri V. Filippov
Joel Moss
Amedeo Caflisch
Michael O. Hottiger
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Protein ADP-ribosylation has emerged as a key post translational modification that regulates several stress responses. Here the authors characterize ARH3 as a major serine-specific mono–ADP-­ribosylhydrolase and use a proteomics approach to identify the cellular targets of ARH3.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6b5383d3e22d404d94e3d6189a490adf
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-02253-1