Reliability and accuracy of Artificial intelligence-based software for cephalometric diagnosis. A diagnostic study

Abstract Background Artificial intelligence (AI) is revolutionizing cephalometric diagnosis in orthodontics, streamlining the patient assessments. This study aimed to assess the reliability, accuracy, and time consumption of artificial intelligence (AI)-based software compared to a conventional digital cephalometric analysis method on 2D lateral cephalogram. Methods 408 lateral cephalometries were analysed using three methods: manual landmark localization, automatic localization, and semi-automatic localization with AI-based software. On each lateral cephalogram, 15 variables were selected, including skeletal, dental, and soft tissue measurements. The difference between the two AI-based software options (automatic and semi-automatic) was compared with the conventional digital technique. The time required to produce a complete cephalometric tracing was evaluated for each method using Student’s t-test. Results Statistically significant differences in the accuracy of landmark positioning were detected among the three different techniques (p