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Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Authors :
Iria Fernandez Botana
Giulia Pagano
Etienne Moussay
Jerome Paggetti
Source :
OncoImmunology, Vol 12, Iss 1 (2023)
Publication Year :
2023
Publisher :
Taylor & Francis Group, 2023.

Abstract

ABSTRACTChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Details

Language :
English
ISSN :
2162402X
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
OncoImmunology
Publication Type :
Academic Journal
Accession number :
edsdoj.6ccff743e491466b95b6ae76421016ba
Document Type :
article
Full Text :
https://doi.org/10.1080/2162402X.2023.2276490