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Exploring racial disparities on the association between allostatic load and cancer mortality: A retrospective cohort analysis of NHANES, 1988 through 2019
- Source :
- SSM: Population Health, Vol 19, Iss , Pp 101185- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Background: Several studies suggest that chronic stress may be associated with increased risk of cancer mortality. Our study sought to determine the association between allostatic load (AL), a measure of cumulative stress, and risk of cancer death; and whether these associations varied by race/ethnicity. Methods: We performed retrospective analysis using National Health and Nutrition Examination Survey (NHANES) years 1988 through 2010 linked with the National Death Index through December 31, 2019. We fit Fine & Gray Cox proportional hazards models to estimate sub-distribution hazard ratios (SHRs) of cancer death between high and low AL status (models adjusted for age, sociodemographics, and comorbidities). Results: In fully adjusted models, high AL was associated with a 14% increased risk of cancer death (adjusted (SHR): 1.14, 95% CI: 1.04–1.26) among all participants and a 18% increased risk of cancer death (SHR:1.18, 95% CI: 1.03–1.34) among Non-Hispanic White (NH-White) adults. When further stratified by age (participants aged
Details
- Language :
- English
- ISSN :
- 23528273
- Volume :
- 19
- Issue :
- 101185-
- Database :
- Directory of Open Access Journals
- Journal :
- SSM: Population Health
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6cf48a5b3b4d83994d27e947ffa29e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ssmph.2022.101185