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In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction

Authors :
Jingyao Wu
Leila J. Mady
Abhijit Roy
Ali Mübin Aral
Boeun Lee
Feng Zheng
Toma Catalin
Youngjae Chun
William R. Wagner
Ke Yang
Humberto E. Trejo Bittar
David Chi
Prashant N. Kumta
Source :
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Wu et al. demonstrate utility of a novel, ultrahigh ductility Mg alloy-based biodegradable stent in vitro and in vivo for use in congenital disorders like pediatric laryngotracheal stenosis. Tested in both bioreactor system and rabbit airway model, these stents display higher corrosion resistance and better in vivo degradation without affecting growth of rabbit airway.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
3
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.6d235ced326f40edb621d01d1466043f
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-020-01400-7