Back to Search Start Over

pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

Authors :
Jianhua Zou
Zheng Li
Yang Zhu
Yucen Tao
Qing You
Fangfang Cao
Qinghe Wu
Min Wu
Junjie Cheng
Jianwei Zhu
Xiaoyuan Chen
Source :
Bioactive Materials, Vol 34, Iss , Pp 414-421 (2024)
Publication Year :
2024
Publisher :
KeAi Communications Co., Ltd., 2024.

Abstract

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently of oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive to the tumor microenvironment (TME) to enhance type I PDT through glutathione (GSH) depletion. Our approach aims to expand the sources of therapeutic benefits by promoting the generation of superoxide radicals (O2−.) while minimizing their consumption. The diisopropyl group within PEG-IR820 serves a dual purpose: it functions as a pH sensor for the disassembly of the NPs to release JSK and enhances intermolecular electron transfer to IR820, facilitating efficient O2−. generation. Simultaneously, the release of JSK leads to GSH depletion, resulting in the generation of nitric oxide (NO). This, in turn, contributes to the formation of highly cytotoxic peroxynitrite (ONOO−.), thereby enhancing the therapeutic efficacy of these NPs. NIR-II fluorescence imaging guided therapy has achieved successful tumor eradication with the assistance of laser therapy.

Details

Language :
English
ISSN :
2452199X
Volume :
34
Issue :
414-421
Database :
Directory of Open Access Journals
Journal :
Bioactive Materials
Publication Type :
Academic Journal
Accession number :
edsdoj.6db49f60f7d64be39e4107257d2d1473
Document Type :
article
Full Text :
https://doi.org/10.1016/j.bioactmat.2023.12.023