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Ginsenoside-Mc1 reduces cerebral ischemia-reperfusion injury in hyperlipidemia through mitochondrial improvement and attenuation of oxidative/endoplasmic reticulum stress
- Source :
- Archives of Biological Sciences, Vol 74, Iss 2, Pp 159-168 (2022)
- Publication Year :
- 2022
- Publisher :
- University of Belgrade, University of Novi Sad, 2022.
-
Abstract
- The neuroprotective effect of ginsenoside-Mc1 (GMc1) in hyperlipidemic rats in the setting of cerebral ischemiareperfusion injury (I/RI), as well as the role of mitochondrial ATP-sensitive potassium (mitoKATP) channels and oxidative/ endoplasmic reticulum (ER) stress, was investigated. Hyperlipidemia (8 weeks) was induced by a high-fat diet in Sprague Dawley rats. GMc1 (10 mg/kg, i.p.) was given to hyperlipidemic rats daily for one month before I/RI. Rat brains were subjected to 2 h of local ischemia followed by 24 h reperfusion. The cerebral infarcted injury was measured by triphenyltetrazolium chloride staining and the levels of oxidative stress indicators were detected by ELISA and spectrophotometry. A fluorometric technique was employed to evaluate mitochondrial function. Western blotting was used to detect changes in the expression of ER stress proteins. GMc1 reduced cerebral infarct volume in hyperlipidemic rats in comparison to untreated ones (P
Details
- Language :
- English
- ISSN :
- 03544664 and 18214339
- Volume :
- 74
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Archives of Biological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6e1f667c82bd49f083c21d8fbd75268a
- Document Type :
- article
- Full Text :
- https://doi.org/10.2298/ABS220212015W