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Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

Authors :
Shihori Tanabe
Jason O’Brien
Knut Erik Tollefsen
Youngjun Kim
Vinita Chauhan
Carole Yauk
Elizabeth Huliganga
Ruthann A. Rudel
Jennifer E. Kay
Jessica S. Helm
Danielle Beaton
Julija Filipovska
Iva Sovadinova
Natalia Garcia-Reyero
Angela Mally
Sarah Søs Poulsen
Nathalie Delrue
Ellen Fritsche
Karsta Luettich
Cinzia La Rocca
Hasmik Yepiskoposyan
Jördis Klose
Pernille Høgh Danielsen
Maranda Esterhuizen
Nicklas Raun Jacobsen
Ulla Vogel
Timothy W. Gant
Ian Choi
Rex FitzGerald
Source :
Frontiers in Toxicology, Vol 4 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively referred to as reactive oxygen and nitrogen species (RONS), has recently become highly relevant in a number of adverse outcome pathways (AOPs) that capture, organize, evaluate and portray causal relationships pertinent to adversity or disease progression. RONS can potentially act as a key event (KE) in the cascade of responses leading to an adverse outcome (AO) within such AOPs, but are also known to modulate responses of events along the AOP continuum without being an AOP event itself. A substantial discussion has therefore been undertaken in a series of workshops named “Mystery or ROS” to elucidate the role of RONS in disease and adverse effects associated with exposure to stressors such as nanoparticles, chemical, and ionizing and non-ionizing radiation. This review introduces the background for RONS production, reflects on the direct and indirect effects of RONS, addresses the diversity of terminology used in different fields of research, and provides guidance for developing a harmonized approach for defining a common event terminology within the AOP developer community.

Details

Language :
English
ISSN :
26733080
Volume :
4
Database :
Directory of Open Access Journals
Journal :
Frontiers in Toxicology
Publication Type :
Academic Journal
Accession number :
edsdoj.6e4603ffc4664fc2936ec3f4a2a4f907
Document Type :
article
Full Text :
https://doi.org/10.3389/ftox.2022.887135