Comparison of Oral Aerobic Bacterial Profile in Patients with Oral Squamous Cell Carcinoma and Patients with Oral Pre Cancerous Lesions, Attending Tertiary Care Centre in Rajasthan

Background: More than 90 percent of oral cancers are squamous cell carcinomas, making them the most frequent kind of malignant tumor in the oral and maxillofacial area. Oral cancer rates are rising rapidly over the globe. Oral malignant tumors may develop when there is an incongruity between the microbiome and the host. Material & Methods: This prospective study was carried out in microbiology department, SMS Medical College, Jaipur. A total of 200 oral swab samples have been collected 100 for control group and 100 for case group and processed for bacterial identification according to standard microbiological guidelines. Results: Among the 100 samples studied from the oral squamous cell carcinoma patients, Pseudomonas species (n = 45) were the predominant isolate, followed by Klebsiella species (n = 26) and Staphylococcus species (n = 15). Of the 100 samples studied among the control group, Micrococci (24) and Diptheroids (23) is the predominant bacteria isolated. Conclusion: Patients with precancerous lesions had a more varied and abundant oral microbiome compared to those with oral cancer and healthy controls but that there was no difference between the groups in terms of overall microbiota composition. When comparing the oral bacterial profiles of those with cancer and those without, there were clear distinctions. Therefore, bacteria may be used as biomarkers in the diagnosis of oral cancer and as therapeutic targets in its therapy. Keywords: Oral microbial profile, oral pre canceous lesions, Oral pre cancerous lesions