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ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

Authors :
Zhe Tian
Keishi Miyata
Tsuyoshi Kadomatsu
Haruki Horiguchi
Hiroyuki Fukushima
Shugo Tohyama
Yoshihiro Ujihara
Takahiro Okumura
Satoshi Yamaguchi
Jiabin Zhao
Motoyoshi Endo
Jun Morinaga
Michio Sato
Taichi Sugizaki
Shunshun Zhu
Kazutoyo Terada
Hisashi Sakaguchi
Yoshihiro Komohara
Motohiro Takeya
Naoki Takeda
Kimi Araki
Ichiro Manabe
Keiichi Fukuda
Kinya Otsu
Jun Wada
Toyoaki Murohara
Satoshi Mohri
Jun K. Yamashita
Motoaki Sano
Yuichi Oike
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Heart responds to increased workload by enlarging cardiomyocytes to preserve function, but in pathologies hypertrophy leads to heart failure. Here the authors show that ANGPTL2 activity in the heart is critical for determining beneficial vs. pathological hypertrophy via its effect on AKT-SERCA2a signaling and myocardial energy.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6eb0ea23c0c43f48342a0be10a7d45b
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms13016