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Role of influenza A virus NP acetylation on viral growth and replication

Authors :
Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6ed0845914b74bd29b55b944319e9373
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01112-3