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Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells

Authors :
Claudia Burrello
Federica Garavaglia
Fulvia Milena Cribiù
Giulia Ercoli
Gianluca Lopez
Jacopo Troisi
Angelo Colucci
Silvia Guglietta
Sara Carloni
Simone Guglielmetti
Valentina Taverniti
Giulia Nizzoli
Silvano Bosari
Flavio Caprioli
Maria Rescigno
Federica Facciotti
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Faecal microbiota transplantation (FMT) is becoming a therapeutic option in several gastrointestinal disorders. Here, Burrello et al. study the immunological mechanisms by which FMT reduces colonic inflammation and initiates the restoration of intestinal homeostasis in a mouse model of colitis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6f140d01828f4beeb27e25c2efa5c440
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07359-8