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Prognosis of Differentiated Thyroid Carcinoma with Initial Distant Metastasis: A Multicenter Study in Korea

Authors :
Hosu Kim
Hye In Kim
Sun Wook Kim
Jaehoon Jung
Min Ji Jeon
Won Gu Kim
Tae Yong Kim
Hee Kyung Kim
Ho-Cheol Kang
Ji Min Han
Yoon Young Cho
Tae Hyuk Kim
Jae Hoon Chung
Source :
Endocrinology and Metabolism, Vol 33, Iss 2, Pp 287-295 (2018)
Publication Year :
2018
Publisher :
Korean Endocrine Society, 2018.

Abstract

BackgroundMost patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prognosis of patients with DTC and initial distant metastasis in Korea.MethodsWe retrospectively reviewed the clinical data of 242 patients with DTC and initial distant metastasis treated from 1994 to 2013, collected from five tertiary hospitals in Korea.ResultsThe patients' median age was 51 years, and 65% were women. They were followed for a median of 7 years. Lung was the most common site of distant metastasis: only lung 149 patients (62%), only bone 49 (20%), other single site one (pleura), and combined sites 43 (40 were lung and bone, two were bone and other site, and one was lung and other site). At the time of diagnosis, 50 patients (21%) had non-radioactive iodine (RAI) avidity. Five-year disease-specific survival (DSS) was 85% and 10-year DSS was 68%, which were better than those in previous studies. After multivariate analysis, old age, male sex, metastatic site, and histologic type (follicular type) were significant factors for poor prognosis. However, negative RAI avidity status was not a significant prognostic factor after adjusting for other variables.ConclusionThe prognosis of Korean patients with DTC and initial distant metastasis was better than in previous studies. Old age, male sex, metastasis site, and histologic type were significant prognostic factors.

Details

Language :
English, Korean
ISSN :
2093596X and 20935978
Volume :
33
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Endocrinology and Metabolism
Publication Type :
Academic Journal
Accession number :
edsdoj.6f2aee03f2c4663a691537ed83dd6a6
Document Type :
article
Full Text :
https://doi.org/10.3803/EnM.2018.33.2.287